H7N9 virus gene mutation, mammals are more susceptible to infection

According to a new study by Japanese experts, some genes of the H7N9 avian influenza virus have been mutated, making it easier to infect mammals and achieve proliferation.

The research team led by Professor of the University of Tokyo, Kazuyuki Kazuo, reported in a new online edition of the British journal Nature that they experimented with viruses collected from Chinese patients and viruses collected from wild ducks. Let these different sources of the virus infect the ferrets, and then investigate whether the infected ferrets will re-infect the ferrets in other cages.

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The researchers found that no ferrets infected the virus from wild ducks, but the virus from the patient spread through droplets, infecting one of the three ferrets. The team analyzed the virus in the infected ferrets and found that the virus showed genetic variation that made the virus more likely to attach to mammalian cells. In addition, the virus has the characteristics of being easily attached to human cells.

People infected with H7N9 avian influenza cases were first discovered at the end of March in Shanghai and Anhui, China, and more than 130 confirmed cases were reported, of which more than 40 died. Researchers believe that the H7N9 avian influenza virus has undergone an important mutation in the human body. Kawaoka Yoshihiro said: "Once the virus can be spread from person to person, it will likely bring great harm to the world."

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